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Researchers at the Technion-Israel Institute of Technology and Rambam Medical Center have demonstrated that mettle cells grown from vulnerable embryonic shoot cells can knit into the host heart and support administer its activity, becoming in effect a biological pacemaker.

This breakthrough may lead to the development of a biological pacemaker and to using heart cells to repair heart tissue destroyed by heart attacks. The study is published in the September 26, 2004 issue of Nature Biotechnology.

“This is extremely important research,” says Dr. David Gutterman, professor of medicine and physiology at the Medical College of Wisconsin and associate director of its Cardiovascular Research Center. “This could lead to a replacement of the mechanical pacemaker, which requires surgery to replace the battery every few years. We could also replace beating cells in patients who have had heart attacks. Dr. Gepstein is on the forefront of heart rhythm research.”

“This is an important proof of concept that heart cells can have the ability to integrate within existing cells,” says lead researcher Dr. Lior Gepstein of the Technion Faculty of Medicine.

Dr. Gepstein and his colleagues were the first to generate human heart tissue in the laboratory, which could be used for testing and creating new drugs for genetic studies, for tissue engineering and for studying the effects of various stresses on the heart. The team, however, wanted to test if the cells could function and integrate within a live host body.

They placed beating human heart cells, derived from the stem cell line, onto rat heart tissue. By recording the electrical activity from both tissues, they were able to show that the two tissues integrated electrically to form a single functional unit in which rat and human cells were beating in perfect synchronicity.

This concept was then tested in living animals with slow heart rates. The team transplanted human pacemaker cells derived from the embryonic stem cell line into the animals’ hearts. Using specialized electrical mapping equipment developed by the Technion researchers, they were able to pinpoint where the heart rate originated within the living animal, which turned out to be at the immediate region containing the transplant. This demonstrated that the implanted cells had integrated into the host heart, and by regulating its pace were behaving like a biological pacemaker.

Technion scientists are widely recognized as pioneers in stem cell research. Dr. Joseph Itskovitz-Eldor was among the team that first discovered in 1998 the potential of stem cells to form any kind of tissue. Technion researchers have since grown heart tissue, blood vessels, and human insulin-secreting cells from embryonic stem cells. And scientists at the Technion are now able to grow an infinite number of cells without a feeder layer, making these cells appropriate for eventual human transplantation.

Heart disease is the leading cause of death in the U.S. Abnormally slow heart rate develops in older patients, who can only survive with an electronic pacemaker. During heart attacks, tissue is destroyed when blood is temporarily cut off to a section of the heart, and this tissue can never be repaired. Cell therapy has the potential to treat these currently nearly untreatable diseases.

Dr. Gepstein says that while obstacles remain before the research leads to cell therapy, these groundbreaking results demonstrate that this type of treatment will be possible.

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It’s one of the biggest controversies in fetal surgery and the cause of heated debate among surgeons and maternal-fetal drug physicians almost the in every respect: What’s the best withdraw to treat twin-twin transfusion syndrome (TTTS), one of the most common conditions requiring fetal surgery and the supreme cause of mortality in twins?

The benchmark, NIH-funded study on TTTS, conducted at 17 centers in the United States, was presented at the annual meeting of the Society for Maternal-Fetal Medicine in San Francisco, and it won’t likely resolve the question of which is the best procedure. The study, led by Timothy Crombleholme, M.D., director of the Fetal Care Center of Cincinnati, shows that the question isn’t which surgical procedure is better, it’s when the procedure is done.

Dr. Crombleholme issued a clarion call to fetal care specialists around the world. “The earlier in gestation TTTS is diagnosed, the more severe the syndrome tends to be,” says Dr. Crombleholme, who is also a pediatric surgeon at Cincinnati Children’s Hospital Medical Center. “We have to shift attention to diagnosing this earlier in the progression of the syndrome and being more aggressive about intervention. We can’t conclude that one therapy is better than another, but it’s apparent that we’re going to compromise survival if treatment isn’t initiated before it gets to be severe.”

In TTTS, the way in which blood flows through the connecting blood vessels on a shared placenta is unequal. As a result, the donor twin has slowed growth and decreased amniotic fluid, while the recipient has too much amniotic fluid and develops a form of heart failure. Without treatment, TTTS is fatal for at least 90 percent of twins, and both twins are at risk for severe complications.

There are two main treatment modalities: amnioreduction, in which excess amniotic fluid is removed from the recipient twin, or a fetoscopic laser procedure to treat the anatomic basis for the syndrome. Until now, the only major study comparing these two treatments for TTTS was the Eurofetus trial, which compared laser and amnioreduction as primary therapies. That study, published in The New England Journal of Medicine in 2004, found that, at six months, there was better survival among twins using laser vs. amnioreduction.

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The NIH-funded study, which began in 2002, required participants to have more severe disease and to have already failed an initial amnioreduction. But when the Eurofetus results were published, everyone thought that laser was superior and stopped referring patients. The American investigators asked that the trial be stopped. Unbeknownst to investigators at that time, the trial oversight committee found significant differences between the two treatment modalities and recommended that the trial be stopped, which it was in May of 2005.

The trial had uncovered higher mortality among recipient twins who received laser treatment. But overall, survival of one or both twins of the same pregnancy was no different between the two treatments. In addition, there was no difference between survival rates of donor twins and recipient twins. How is this possible?

“It turns out that in amnioreduction, there were significant numbers of treatment failures, so patients were dropping out in the amnioreduction arm because they were failing therapy, whereas they were dying in the laser therapy,” says Dr. Crombleholme. Statistically, these patients are considered to have had the same outcome: a treatment failure. So, ultimately, there was no significant difference in survival of one or both twins between the two treatments.”

What Dr. Crombleholme and his colleagues did find were two predictors of success. One was the stage of severity of TTTS. The other was the echocardiographic findings of heart failure. Fetal echocardiography, which is not done routinely in TTTS in most centers, should be done whenever a patient is diagnosed, according to Dr. Crombleholme

“While one cannot conclude from this study that one therapy is better than the other, neither can one conclude that they’re equivalent, because it included patients who failed an initial amnioreduction and then went on to get laser,” says Dr. Crombleholme.

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Researchers at the University of Pennsylvania School of Remedy and Queen’s University, Ontario, Canada relate in the online edition of Nature Medicine this week that the COX enzymes - well-known into their contrasting role in cardiovascular biology - interact physically to form a theretofore unrecognized biochemical partnership and act the part of in the development of blood vessels in a mouse plus ultra. Collaborators Garret FitzGerald, MD, Number one of Penn’s Institute on account of Translational Medicine and Therapeutics, and Colin Funk from Queen’s University, say that the findings suggest brand-new biological, developmental, and therapeutic roles looking for COX enzymes and prompt a re-estimate of principal assumptions with respect to the role of COX enzymes in plague.

COX-2 is the object of the now intimate COX inhibitors Vioxx and Celebrex. COX-1, the less celebrated sister, is the target of low-portion aspirin and older drugs, such as Advil and Naprosyn, which inhibit both COX-1 and COX-2 to preclude heart disease.

Researchers have known in compensation some time that COX-1 and COX-2 two of a kind up to ceremony in the body. Even notwithstanding they are interlocked, on the contrary one of them is active at a time in processing their substrate, arachidonic acid - from which prostaglandins, the fatty mediators of pain, inflammation, and heart attacks - are formed. The molecular structures of COX-1 and COX-2 are remarkably compare favourably with, but a subtle modulation in their arrangement permits the construction of drugs that are selective in their inhibition as regards COX -2.

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For this study the researchers developed a novel genetic mouse sitter that mimics the physiology of COX-2 stricture. The investigators demonstrated that the COX-1:COX-2 partnership, or heterodimer, appears to play a touchy role in the mutation that occurs in the blood vessels of newly born mice, shortly after start, namely the closing of the ductus arterious. This necessary developmental reduce intervene permits newborns to function independently from their mother.

“These observations prompt us to scrutinize new roles for the COX enzymes in biology,” says FitzGerald. “Perhaps their incorporate will extend to other enzymes, such as the lipoxygenases and the nitric oxide synthases, in ways that induce us to re-evaluate basic assumptions helter-skelter the role of COX enzymes in physiology and blight.”

“Perhaps this combination of COX enzymes drive represent a new drug target,” speculates Funk. “Blocking the COX dimer may alter the ideal of usefulness and/or safeness that we associate with existing non-steroidal anti-riotous drugs.” Funk, who has collaborated with FitzGerald at Penn all over the last decade on this line of scrutinize, is infrequently the Canada Research Throne of Physiology at Queen’s University, Ontario.

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Article adapted by Medical News Today from imaginative press release.
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Co-authors are by Ying Yu, Jinjin Fan, Xin-Sheng Chen and Dairong Wong, all postdoctoral fellows at Penn’s Pioneer through despite Translational Medicine and Therapeutics; Andres Klein-Szanto, Fox Chase Cancer Center, Philadelphia; and Robert Campbell, from Queens University.

This work was supported by grants from the National Institutes of Health and the Canadian Institutes of Healthfulness Delve into and the Consideration and Stroke Foundation of Ontario.

This release and kindred images can be set at http://www.uphs.upenn.edu/news/

PENN Medicine is a $2.9 billion enterprise dedicated to the related missions of medical learning, biomedical research, and tainted-grandeur patient anguish. PENN Medicine consists of the University of Pennsylvania School of Pharmaceutical (founded in 1765 as the nation’s primary medical school) and the University of Pennsylvania Vigour System.

Penn’s Style of Medicine is ranked no. 2 in the country for counterfoil of NIH research funds; and ranked no. 3 in the nation in U.S. Press release and Happy Report’s most recent ranking of top research-oriented medical schools. Supporting 1,400 fulltime cleverness and 700 students, the Group of Medicine is recognized worldwide for its superior education and training of the next generation of physician-scientists and leaders of learned medicament.

The University of Pennsylvania Health Organized whole includes three hospitals [Hospital of the University of Pennsylvania, which is firmly ranked joke of the nation's few "Honor Roll" hospitals by U.S. Front-page news and Humankind Report; Pennsylvania Facility, the nation's chief hospital; and Penn Presbyterian Medical Center]; a faculty practice plan; a train-care provider network; two multispecialty attendant facilities; and home care and hospice.

Contact: Karen Kreeger
University of Pennsylvania Mould of Physic

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Adolescents who participate in physical teaching at school are more reasonable to maintain a normal incline as young adults, according to a study by researchers at the Johns Hopkins Bloomberg School of Disreputable Condition.

For each weekday of physical education at school the odds of being an overweight adult decreased by 5 percent. Participation in all five days of physical education decreased the odds of being an overweight adult by 28 percent. The study is published in the January 2008 edition of the journal, Archives of Pediatrics & Adolescent Medicine.

“These findings underscore the important role that school-based and extracurricular physical activities play in reducing the likelihood of becoming an overweight adult,â€? said Robert Wm. Blum, MD, MPH, PhD, the study’s senior author. “While physical education was not a good weight-loss mechanism over time, it appears to have a positive impact in helping teenagers maintain a healthy weight into young adulthood,â€? added Blum, who is the Bloomberg School’s William H. Gates Sr. Professor and Chair in Population and Reproductive Health.

The Hopkins team studied 3,345 teens in grades eight through 12 who took part in the National Longitudinal Study of Adolescent Health at which time the teens were surveyed on their participation in physical education and physical activities outside of school. The researchers then followed up with the participants five years after leaving school to check their height and weight.

The researchers found that increased participation in physical education and certain extracurricular physical activities decreased the likelihood of being overweight as an adult. The likelihood of being an overweight adult was most reduced among teens who participated in wheel-related extracurricular activities, such as rollerblading, biking or skate-boarding more than 4 times per week. These teens were more than twice as likely to maintain a normal weight as adults compared to their less active peers. However, no impact was detected when physical activities were performed fewer than three times per week.

The American Academy of Pediatrics and the U.S. Department of Health and Human Services recommend physical education at all grade levels. Studies show that less than half of high school students are enrolled in physical education courses. Only 6 percent of junior high schools and 5 percent of senior high schools offer daily physical education, according to the Institute of Medicine.

“Sixteen percent of adolescents in the United States are overweight or obese and 85 percent of obese teens will become obese adults. School-based physical education could be a low-cost strategy and a long-lasting solution to adult obesity,� said Blum.

http://www.jhsph.edu/

Australian experts are telling parents to wean their babies off the pluck when they are twelve months worn out.

The director of the Sydney-based Centre in the service of Kindred Health and Midwifery, Leslie Barclay, says cows’ tap and sweet drinks used for assuage and to soothe babies to sleep may twaddle teeth and motivate consideration infections.

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They say that cow’s milk replaces vital nutrients which the child should be having. Momentous nutrients such as iron could be missed if the baby carries on drinking milk from the sauce a contain.

‘Cows’ wring is not a complete chow for babies after six months of human being and after 12 months of life, if it is replacing other viands, babies can become anaemic and beget other form problems that may result,’ they say.

According to the Family Health and Midwifery Centre, quiet children to repose with bottled wring or fragrant drinks may rot young teeth.

‘We wouldn’t put an adult to bed with something to suck, something to soothe them, extraordinarily if that soothing is affluent to add unnecessary calories or may result in some health problems,’ they.

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Dental professionals will tell every parent that the biggest challenge when it comes to kids’ oral care habits is the rush to brush. Two minutes – one minute on the uppers and one minute on the lowers - is the recommended time it takes to properly brush. However, kids will most often give their teeth a few ineffective scrubs, spit and that’s it. Consequently, the FIRE FLY by DR. FRESH, a bright and sparkly children’s toothbrush that lights up and flashes for one minute, is inspiring kids everywhere to brush longer.

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Backed by extensive research and development, this soft bristle toothbrush contains an LCD light that incorporates “blinking technology,� flashing for 60-seconds when pressed at the base. The Fire Fly allots for one-minute upper and one-minute lower teeth brushing, separating the cycles to ensure that kids get into the pattern of one solid minute on each arch.

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If you take folic acid supplements you could be reducing your chances of developing sensitivity complaint or soothe, vote researchers from the Wolfson Institute in favour of Remedy Remedy, and the Barts & The London
Queen Mary’s School of Medicine and Dentistry, UK.

The researchers looked at earlier studies and found that folic acid reduces levels of homocysteine, which lowers a person’s chances of developing heart disease. Homocysteine is an amino acid in the blood. Studies have shown that too much homocysteine in the blood is linked to a higher hazard of cardiovascular disease, stroke and preripheral vascular affliction.

Dr Wald, team leader, from the Queen Mary’s School of Medicine and Dentistry, said “Folic acid is a much undervalued vitamin. Not only does it prevent the serious birth defect spina bifida, but the evidence that it can reduce the risk of heart strike at and stroke is becoming increasingly persuasive”.

The party also looked at studies of patients with a genetic changing which affects helter-skelter 10% of people. These people experience higher than normal levels of homocysteine. They wanted to find elsewhere whether folic acid consumption altered their levels of homocysteine. They found that the consumption of folic acid brought their levels of homocysteine down to average.

Dr. Wald said that all the evidence they looked through, issue together, is compelling - that folic acid does reduce the chance of heart blight and strokes.

Mellow Dietary Sources of Folic Acid

– Swart green, shady vegetables
– Fortified breakfast cereals, enriched grain products
– Liver, other organ meats
– Lightly cooked beans, peas (too much cooking will exterminate the folate content)
– Nuts, seeds
– Oranges, grapefruits
– Sprouts
– Poultry
– Whole wheat bread

“Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence”
David S Wald, Nicholas J Wald, Joan K Morris
BMJ 2006;333:1114-1117 (25 November)
doi:10.1136/bmj.39000.486701.68
Click here to appreciate analysis and comment (BMJ)

Written by: Christian Nordqvist
Copy editor: Medical Scandal Today

Copyright: Medical News Today

Not to be reproduced without franchise of Medical Intelligence Today

The American College of Obstetricians and Gynecologists (ACOG) joins more than 100 organizations representing immigrants’ rights, women’s rights, public health, medicine, and reproductive justice in urging the Centers for Complaint Direction and Inhibiting (CDC) to remove the woman papillomavirus (HPV) vaccine from the list of required vaccinations for female immigrants seeking undying residence or coming to the US. ACOG also supports the request that the CDC unreflected the US Office of Citizenship and Immigration Services to suspend the HPV vaccination requirement for immigrants seeking to adjust their immigration standing or to obtain visas to the US.

In a January 26 scholarship precisely to Richard Besser, MD, acting head of the CDC, ACOG was among those organizations voicing collective opposition to the recent requirement that female immigrants ages 11 to 26 be immunized against HPV. The precondition was finalized in July 2008 and took basically in August. The organizations request that the CDC direct the Prediction Panel on Immunization Practices (ACIP)* to limit its suggestion to state that the HPV vaccination should not be mandated to immigrants. ACIP recommended in 2007 that the HPV vaccine be administered to females ages 11 to 26 in the US. This recommendation then became an unavoidable qualification for nearing immigrants when the government updated its vaccination inventory in July 2008.

Although ACOG strongly recommends the HPV vaccine, it does not withstand mandatory HPV vaccination. Prospective immigrant women should have the same moment as American women to beat it an up on decision about whether or not to be vaccinated against HPV.

*ACIP consists of 15 experts in the fields associated with immunizations who are selected by the secretary of the US Department of Health and Human Services to provide advice and direction to the secretary, the ally secretary in the service of robustness, and the CDC on the control of vaccine-preventable diseases. ACIP develops written recommendations for the routine administration of vaccines to children and adults in the civilian population.

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The American College of Obstetricians and Gynecologists is the national medical institution representing upward of 52,000 members who provide health care for women.

American College of Obstetricians and Gynecologists

The use of human papillomavirus (HPV) DNA testing as an sign screening step followed by triage with a example Pap test (cytology) and copy HPV DNA testing may boost waxing the accuracy of cervical cancer screening, according to a study in the Jan. 13 online issue of the Register of the National Cancer Institute. Compared to cytology unexcelled, the screening strategy improved detection of precancerous growths without a great increase in the number of false-positive tests.

Randomized trials require shown that using DNA testing towards HPV - which is known to cause cervical cancer - in screening programs would increase detection of cervical intraepithelial neoplasia (CIN) compared with cytology. Respect, HPV DNA testing also results in a well-established increase in inaccurate-positive tests, which lead to disposable and costly retesting.

In the current study, Joakim Dillner, M.D. of Lund University in Malmö, Sweden, and colleagues compared the efficacy of 11 another screening strategies that cast-off HPV DNA testing, cytology, or a combination of the two. To evaluate the different strategies the investigators retrospectively analyzed matter from 6,257 women who were enrolled in the intervention arm of a large-hearted randomized screening fling, called Swedescreen, in which HPV DNA testing was hand-me-down in above moreover to standard cytology.

As seen in above-named trials, the use of HPV DNA testing in conjunction with cytology increased the screening efficacy, detecting 35 percent more cases of CIN grade 3 or worse, compared with cytology alone. The strategy, in what way, doubled the tally of tests required. By contrast, the use of the HPV primary screen with cytology and repeat HPV testing resulted in a 30 percent higher detection rate compared to cytology alone, with only a 12 percent increase in the number of tests required. In this approach, all women with HPV infections detected on the primary screening went on to have a standard Pap test; those with normal cytology then had a repeat HPV DNA test at least 1 year later.

“In conclusion, our data evince that using HPV DNA testing as peak screening followed by cytological triage and retell HPV DNA testing of women with normal cytology who are HPV DNA pigheaded after at least 1 year is a viable design for incorpo¬rating HPV testing in primary cervical screening because it improves supersensitivity and maintains a high [positive predictive value], thus minimizing unnecessary referrals,” the authors write.

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Article adapted by Medical Gossip Today from true press let go.
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Citation:

Naucler P, et al. Efficacy of HPV DNA Testing with Cytology Triage and/or Reproduction HPV DNA Testing in Primary Cervical Cancer Screening. Record book of the National Cancer Institute2009;101:88-99.

The Gazette of the National Cancer Institute Institute is published by Oxford University Press and is not affiliated with the Governmental Cancer Institute. Visit the Record book online at http://jnci.oxfordjournals.org/.

Provenience: Caroline McNeil

Journal of the National Cancer Institute

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